Synthesis of tetrahydro-2-furyl derivatives of 5-substituted uracils.
نویسندگان
چکیده
منابع مشابه
Furan derivatives. ЬХХП. Synthesis and some properties of l-(5-nitro-2-furyl)- -2- (5-aryl-2-furyl)ethylenes
Wittig reaction has recently been applied also in the preparation of 5-nitrofuran derivatives of ethylene [1—5]. The quoted syntheses were accomplished starting either from 5-nitrofurfuryl halides which were converted into 5-nitrofurfurylidenephosphoranes and subsequent condensation of the latter with carbonyl compounds [1—4], or the intermediate phosphoranes were prepared from other furfuryl h...
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6-chloro-5-ethyl-, n-propyl- and isopropyluracils 5a-c were efficiently prepared from the corresponding 5-alkybarbituric acids 3a-c via treatment with phosphorus oxychloride and N,N-dimethylaniline to yield the corresponding 5-alkyl-2,4,6-trichloro-pyrimidines 4a-c, which were selectively hydrolyzed by heating in 10% aqueous sodium hydroxide for 30 minutes. The reaction of compounds 5a-c with 1...
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The enantiomerically and diastereomerically pure tricyclic oxazolidine cis-10 was prepared in a five step synthesis starting with 1-bromo-2-iodobenzene. Me3SiCN and allylSiMe3 reacted with cis-10 in the presence of TiCl4 to form the nitrile (3S)-11 and the allyl derivative (3S)-12 with high diastereoselectivity. The hydrogenolytic removal of the chiral auxiliary failed, since the endocyclic ben...
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Oxidation of uracil (U) and thymine (5-Me-U) are believed to play a role in genetic instability because of the changes these oxidations cause in the ionization constants (pKa values), which in turn affects the base pairing and hence coding. However, interpretation of the experimental evidence for the changes of pKa with substitution at U has been complicated by the presence of two sites (N1 and...
متن کاملSynthesis of Some Nitrogen Functional Derivatives of 5-substituted-6-azauracil as Biologically Active Compounds
3-Arylhydrazono-2,4-dioxo-4-phenylbutanoates have been prepared by the coupling of benzoylpyruvate with aryldiazonium chlorides. Reactions of the 3-arylhydrazono-2,4- dioxo-4-phenylbutanoates with 1-aminoguanidine, semicarbazide, and thiosemicarbazide gave 5-substituted 2-imino-6-azauracil (3a), 6-azauracil (3b), and 2-thio-6-azauracil (3c), respectively. The analytical data of these compounds ...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1979
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.27.899